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H4A3
$40.00
 
  
 
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Antigen: Lysosomal-associated membrane protein 1; Lamp-1 ; CD107a

Hybridoma Cells Available: No
Antigen Species: Human Depositor: August, J.T. / Hildreth, J.E.K.
Antigen Sequence: Depositors Institution: The Johns Hopkins University School of Medicine
Antigen Molecular Weight: 44.8 kDa Human Protein Atlas: Link
Alternate Antigen Name: Depositors Notes: This antibody recognizes a membrane glycoprotein which interacts with selectins.
Gene: LAMP1 Immunogen: Adherent spleen cells
Alternate Gene Names: Immunogen Sequence:
Isotype: MIgG1 Alternate Antibody Name: CD107a
Clonality: Monoclonal Additional Information: For experiments involving live cells and tissue, H4A3 supernatant is available without the antimicrobial ProClin. Contact us at 319-335-3826 or dshb@uiowa.edu for special ordering instructions.
Epitope Mapped: No Myeloma Strain: P3X653-Ag8
Epitope Location or Sequence: Uniprot ID:
Host Species: mouse Entrez Gene ID:
Additional Characterization: Link Antibody Registry ID: AB_2296838
   
Positive Tested Species Reactivity: Hamster, Human, Primate, Rat Recommended Applications: Immunofluorescence, Immunohistochemistry, Western Blot
   
These hybridomas were created by your colleagues. Please acknowledge the hybridoma contributor and the Developmental Studies Hybridoma Bank (DSHB) in the Materials and Methods of your publications. Please email the citation to us.
For your Materials & Methods section:
H4A3 was deposited to the DSHB by August, J.T. / Hildreth, J.E.K. (DSHB Hybridoma Product H4A3)
All cell products contain the antimicrobial ProClin. See our FAQ section for additional information.  

 

Identification of two lysosomal membrane glycoproteins.
Chen JW, Murphy TL, Willingham MC, Pastan I, August JT
The Journal of cell biology 1985 Jul

Expression of the lysosomal-associated membrane protein-1 (LAMP-1) in astrocytomas.
Jensen SS, Aaberg-Jessen C, Christensen KG, Kristensen B
International journal of clinical and experimental pathology 2013

Prosaposin deficiency -- a rarely diagnosed, rapidly progressing, neonatal neurovisceral lipid storage disease. Report of a further patient.
Elleder M, Jerábková M, Befekadu A, Hrebícek M, Berná L, Ledvinová J, Hůlková H, Rosewich H, Schymik N, Paton BC, Harzer K
Neuropediatrics 2005 Jun

A screen of Coxiella burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesis.
Newton HJ, Kohler LJ, McDonough JA, Temoche-Diaz M, Crabill E, Hartland EL, Roy CR
PLoS pathogens 2014 Jul

Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells.
Sudhan DR, Siemann DW
Clinical & experimental metastasis 2013 Oct

The Francisella tularensis migR, trmE, and cphA genes contribute to F. tularensis pathogenicity island gene regulation and intracellular growth by modulation of the stress alarmone ppGpp.
Faron M, Fletcher JR, Rasmussen JA, Long ME, Allen LA, Jones BD
Infection and immunity 2013 Aug

Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells: role of autophagy and JNK activation.
Notte A, Ninane N, Arnould T, Michiels C
Cell death & disease 2013 May 16

An extended proteome map of the lysosomal membrane reveals novel potential transporters.
Chapel A, Kieffer-Jaquinod S, Sagné C, Verdon Q, Ivaldi C, Mellal M, Thirion J, Jadot M, Bruley C, Garin J, Gasnier B, Journet A
Molecular & cellular proteomics : MCP 2013 Jun

Host pathways important for Coxiella burnetii infection revealed by genome-wide RNA interference screening.
McDonough JA, Newton HJ, Klum S, Swiss R, Agaisse H, Roy CR
mBio 2013 Jan 29

A lysozyme-like protein in Brucella abortus is involved in the early stages of intracellular replication.
Del Giudice MG, Ugalde JE, Czibener C
Infection and immunity 2013 Mar

Extracellular amastigotes of Trypanosoma cruzi are potent inducers of phagocytosis in mammalian cells.
Fernandes MC, Flannery AR, Andrews N, Mortara RA
Cellular microbiology 2013 Jun

Intracellularly induced cyclophilins play an important role in stress adaptation and virulence of Brucella abortus.
Roset MS, García Fernández L, DelVecchio VG, Briones G
Infection and immunity 2013 Feb

Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann-Pick type C disease fibroblasts.
Yu T, Chung C, Shen D, Xu H, Lieberman AP
Human molecular genetics 2012 Jul 15

Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs.
Torres AG, Fabani MM, Vigorito E, Williams D, Al-Obaidi N, Wojciechowski F, Hudson RH, Seitz O, Gait MJ
Nucleic acids research 2012 Mar

LAMP2 microdeletions in patients with Danon disease.
Yang Z, Funke BH, Cripe LH, Vick GW 3rd, Mancini-Dinardo D, Peña LS, Kanter RJ, Wong B, Westerfield BH, Varela JJ, Fan Y, Towbin JA, Vatta M
Circulation. Cardiovascular genetics 2010 Apr

Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment.
Gao W, Kang JH, Liao Y, Ding WX, Gambotto AA, Watkins SC, Liu YJ, Stolz DB, Yin XM
The Journal of biological chemistry 2010 Jan 8

The Salmonella effector SptP dephosphorylates host AAA+ ATPase VCP to promote development of its intracellular replicative niche.
Humphreys D, Hume PJ, Koronakis V
Cell host & microbe 2009 Mar 19

Loss of the Batten disease gene CLN3 prevents exit from the TGN of the mannose 6-phosphate receptor.
Metcalf DJ, Calvi AA, Seaman MNj, Mitchison HM, Cutler DF
Traffic (Copenhagen, Denmark) 2008 Nov

Generalized lysosome-associated membrane protein-2 defect explains multisystem clinical involvement and allows leukocyte diagnostic screening in Danon disease.
Fanin M, Nascimbeni AC, Fulizio L, Spinazzi M, Melacini P, Angelini C
The American journal of pathology 2006 Apr

Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking.
Li Y, Chin LS, Levey AI, Li L
The Journal of biological chemistry 2002 Aug 2

PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1).
Liu TF, Kandala G, Setaluri V
The Journal of biological chemistry 2001 Sep 21

The Exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi.
Caler EV, Chakrabarti S, Fowler KT, Rao S, Andrews NW
The Journal of experimental medicine 2001 May 7

Fibrin deposited in the Alzheimer's disease brain promotes neuronal degeneration.
Cortes-Canteli M, Mattei L, Richards AT, Norris EH, Strickland S
Neurobiology of aging 2015 Feb

A screen of Coxiella burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesis.
Newton HJ, Kohler LJ, McDonough JA, Temoche-Diaz M, Crabill E, Hartland EL, Roy CR
PLoS pathogens 2014 Jul

Expression of the lysosomal-associated membrane protein-1 (LAMP-1) in astrocytomas.
Jensen SS, Aaberg-Jessen C, Christensen KG, Kristensen B
International journal of clinical and experimental pathology 2013

Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells.
Sudhan DR, Siemann DW
Clinical & experimental metastasis 2013 Oct

The Francisella tularensis migR, trmE, and cphA genes contribute to F. tularensis pathogenicity island gene regulation and intracellular growth by modulation of the stress alarmone ppGpp.
Faron M, Fletcher JR, Rasmussen JA, Long ME, Allen LA, Jones BD
Infection and immunity 2013 Aug

Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells: role of autophagy and JNK activation.
Notte A, Ninane N, Arnould T, Michiels C
Cell death & disease 2013 May 16

An extended proteome map of the lysosomal membrane reveals novel potential transporters.
Chapel A, Kieffer-Jaquinod S, Sagné C, Verdon Q, Ivaldi C, Mellal M, Thirion J, Jadot M, Bruley C, Garin J, Gasnier B, Journet A
Molecular & cellular proteomics : MCP 2013 Jun

Host pathways important for Coxiella burnetii infection revealed by genome-wide RNA interference screening.
McDonough JA, Newton HJ, Klum S, Swiss R, Agaisse H, Roy CR
mBio 2013 Jan 29

A lysozyme-like protein in Brucella abortus is involved in the early stages of intracellular replication.
Del Giudice MG, Ugalde JE, Czibener C
Infection and immunity 2013 Mar

Extracellular amastigotes of Trypanosoma cruzi are potent inducers of phagocytosis in mammalian cells.
Fernandes MC, Flannery AR, Andrews N, Mortara RA
Cellular microbiology 2013 Jun

Intracellularly induced cyclophilins play an important role in stress adaptation and virulence of Brucella abortus.
Roset MS, García Fernández L, DelVecchio VG, Briones G
Infection and immunity 2013 Feb

Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann-Pick type C disease fibroblasts.
Yu T, Chung C, Shen D, Xu H, Lieberman AP
Human molecular genetics 2012 Jul 15

Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs.
Torres AG, Fabani MM, Vigorito E, Williams D, Al-Obaidi N, Wojciechowski F, Hudson RH, Seitz O, Gait MJ
Nucleic acids research 2012 Mar

LAMP2 microdeletions in patients with Danon disease.
Yang Z, Funke BH, Cripe LH, Vick GW 3rd, Mancini-Dinardo D, Peña LS, Kanter RJ, Wong B, Westerfield BH, Varela JJ, Fan Y, Towbin JA, Vatta M
Circulation. Cardiovascular genetics 2010 Apr

Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment.
Gao W, Kang JH, Liao Y, Ding WX, Gambotto AA, Watkins SC, Liu YJ, Stolz DB, Yin XM
The Journal of biological chemistry 2010 Jan 8

The Salmonella effector SptP dephosphorylates host AAA+ ATPase VCP to promote development of its intracellular replicative niche.
Humphreys D, Hume PJ, Koronakis V
Cell host & microbe 2009 Mar 19

Loss of the Batten disease gene CLN3 prevents exit from the TGN of the mannose 6-phosphate receptor.
Metcalf DJ, Calvi AA, Seaman MNj, Mitchison HM, Cutler DF
Traffic (Copenhagen, Denmark) 2008 Nov

Generalized lysosome-associated membrane protein-2 defect explains multisystem clinical involvement and allows leukocyte diagnostic screening in Danon disease.
Fanin M, Nascimbeni AC, Fulizio L, Spinazzi M, Melacini P, Angelini C
The American journal of pathology 2006 Apr

Prosaposin deficiency -- a rarely diagnosed, rapidly progressing, neonatal neurovisceral lipid storage disease. Report of a further patient.
Elleder M, Jerábková M, Befekadu A, Hrebícek M, Berná L, Ledvinová J, Hůlková H, Rosewich H, Schymik N, Paton BC, Harzer K
Neuropediatrics 2005 Jun

Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking.
Li Y, Chin LS, Levey AI, Li L
The Journal of biological chemistry 2002 Aug 2

PDZ domain protein GIPC interacts with the cytoplasmic tail of melanosomal membrane protein gp75 (tyrosinase-related protein-1).
Liu TF, Kandala G, Setaluri V
The Journal of biological chemistry 2001 Sep 21

The Exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi.
Caler EV, Chakrabarti S, Fowler KT, Rao S, Andrews NW
The Journal of experimental medicine 2001 May 7

Identification of two lysosomal membrane glycoproteins.
Chen JW, Murphy TL, Willingham MC, Pastan I, August JT
The Journal of cell biology 1985 Jul