Anti-GHR-ext mAb 74.3
Catalog Fields
Clone ID/Product Name: Anti-GHR-ext mAb 74.3
Available to For-Profits: No
Alternate Antibody Name:
Gene Symbol: GHR
Ab Isotype: MIgG1, kappa light chain
Gene Name:
Antibody Registry ID: AB_2943484
Uniprot ID: P19941
Entrez Gene ID: 100009325
Clonality: Monoclonal
Immunogen: GST fusion protein
Clone:
Immunogen Sequence: a.a. 1-246
Myeloma Strain: P3X63-Ag8.653
Epitope Mapped: No
Antigen Name: Growth hormone receptor
Epitope Location or Sequence: a.a. 128-246 subdomain 2
Alternate Antigen Name:
Deposit Date: 8/24/2022
Antigen Molecular Weight: 71.0 kDa
Depositor: Frank, S.J.
Antigen Sequence:
Depositor Institution: University of Alabama at Birmingham
Antigen Species: Rabbit
Depositor Notes: The epitope of this antibody is in extracellular domain 2. This mAb does not recognize mouse or rat GHR.
Host Species: mouse
Hybridoma Cells Available (Non-Profit): Yes
Confirmed Species Reactivity: Bovine, Human, Porcine, Rabbit
Additional Information: This antibody or its Fab antagonize GH signaling in vivo and in vitro. The antibody also blocks inducible GHR metalloproteolyaia and consequent GH binding protein shedding.
Recommended Applications: Function Blocking, Immunofluorescence, Immunoprecipitation
All cell products contain the antimicrobial ProClin. Click here for additional information.
These hybridomas were created by your colleagues. Please acknowledge the hybridoma contributor and the Developmental Studies Hybridoma Bank (DSHB) in the Materials and Methods of your publications. Please email the citation to us.
For your Materials & Methods section:
Anti-GHR-ext mAb 74.3 was deposited to the DSHB by Frank, S.J. (DSHB Hybridoma Product Anti-GHR-ext mAb 74.3)
Storage and Handling Recommendations
Usage Recommendations
4 References
Initial Publication
Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth hormone signaling.
Frank SJ
The Journal of biological chemistry 273.4 (1998 Jan 23): 2344-54.