Product Form
Supernatant 1.0 ml
Concentrate 0.1 ml
Frozen Cells 1 vial
Growing Cells 1 vial
DSHB Data Sheet
Tell a Friend
Antigen: Discs large (Drosophila)
Hybridoma Cells Available: Yes
Antigen Species: Drosophila
Depositor: Goodman, C.
Antigen Sequence:
Depositors Institution: University of California, Berkeley
Antigen Molecular Weight: Predicted: 106.7 kDa
Human Protein Atlas:
Link
Positive Tested Species Reactivity: Drosophila
Depositors Notes:
Gene: dlg1
Immunogen: GST-PDZ2-GST fusion protein; recombinant.
Alternate Gene Names: DLG; DLG-A; DLG1; DlgA; DlgS97; Dmel\CG1725;
Immunogen Sequence: same as the antigen
Isotype: MIgG1
Alternate Antibody Name: discs large 1, isoform L
Clonality: Monoclonal
Alternate Antigen Name:
Epitope Mapped: Yes
Myeloma Strain: P3 x 63 Ag8.653
Epitope Location or Sequence: a.a 439–756
Uniprot ID:
Host Species: mouse
Entrez Gene ID:
Additional Characterization:
Link
Antibody Registry ID:
AB_528203
Additional Information: RRID: AB_528203
Recommended Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
These hybridomas were created by your colleagues. Please acknowledge the hybridoma contributor and the Developmental Studies Hybridoma Bank (DSHB) in the Materials and Methods of your publications. Please email the citation to us.
For your Materials & Methods section:
4F3 anti-discs large was deposited to the DSHB by Goodman, C. (DSHB Hybridoma Product 4F3 anti-discs large)
All cell products contain the antimicrobial ProClin. See our FAQ section for additional information.
Subcellular mapping of dendritic activity in optic flow processing neurons. Hopp E, Borst A, Haag J Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 2014 May
Stathmin is required for stability of the Drosophila neuromuscular junction. Graf ER, Heerssen HM, Wright CM, Davis GW, DiAntonio A The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Oct 19
Drosophila adducin regulates Dlg phosphorylation and targeting of Dlg to the synapse and epithelial membrane. Wang S, Yang J, Tsai A, Kuca T, Sanny J, Lee J, Dong K, Harden N, Krieger C Developmental biology 2011 Sep 15
LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. Lee S, Liu HP, Lin WY, Guo H, Lu B The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Dec 15
Formation of a Bazooka-Stardust complex is essential for plasma membrane polarity in epithelia. Krahn MP, Bückers J, Kastrup L, Wodarz A The Journal of cell biology 2010 Sep 6
Rab3 dynamically controls protein composition at active zones. Graf ER, Daniels RW, Burgess RW, Schwarz TL, DiAntonio A Neuron 2009 Dec 10
Regulation of postsynaptic structure and protein localization by the Rho-type guanine nucleotide exchange factor dPix. Parnas D, Haghighi AP, Fetter RD, Kim SW, Goodman CS Neuron 2001 Nov 8
Drosophila adducin regulates Dlg phosphorylation and targeting of Dlg to the synapse and epithelial membrane. Wang S, Yang J, Tsai A, Kuca T, Sanny J, Lee J, Dong K, Harden N, Krieger C Developmental biology 2011 Sep 15
External and circadian inputs modulate synaptic protein expression in the visual system of Drosophila melanogaster. Krzeptowski W, Górska-Andrzejak J, Kijak E, Görlich A, Guzik E, Moore G, Pyza EM Frontiers in physiology 2014
Subcellular mapping of dendritic activity in optic flow processing neurons. Hopp E, Borst A, Haag J Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 2014 May
Synaptic abnormalities in a Drosophila model of Alzheimer's disease. Mhatre SD, Satyasi V, Killen M, Paddock BE, Moir RD, Saunders AJ, Marenda DR Disease models & mechanisms 2014 Mar
Loss of the spectraplakin short stop activates the DLK injury response pathway in Drosophila. Valakh V, Walker LJ, Skeath JB, DiAntonio A The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Nov 6
Drosophila cyfip regulates synaptic development and endocytosis by suppressing filamentous actin assembly. Zhao L, Wang D, Wang Q, Rodal AA, Zhang YQ PLoS genetics 2013 Apr
Tuberous sclerosis complex regulates Drosophila neuromuscular junction growth via the TORC2/Akt pathway. Natarajan R, Trivedi-Vyas D, Wairkar YP Human molecular genetics 2013 May 15
Neurofibromin mediates FAK signaling in confining synapse growth at Drosophila neuromuscular junctions. Tsai PI, Wang M, Kao HH, Cheng YJ, Walker JA, Chen RH, Chien CT The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Nov 21
Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes. Neumüller RA, Wirtz-Peitz F, Lee S, Kwon Y, Buckner M, Hoskins RA, Venken KJ, Bellen HJ, Mohr SE, Perrimon N Genetics 2012 Mar
Three Drosophila liprins interact to control synapse formation. Astigarraga S, Hofmeyer K, Farajian R, Treisman JE The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Nov 17
Formation of a Bazooka-Stardust complex is essential for plasma membrane polarity in epithelia. Krahn MP, Bückers J, Kastrup L, Wodarz A The Journal of cell biology 2010 Sep 6
glaikit is essential for the formation of epithelial polarity and neuronal development. Dunlop J, Morin X, Corominas M, Serras F, Tear G Current biology : CB 2004 Nov 23
Detection and differentiation of picornaviruses in clinical samples following genomic amplification. Olive DM, Al-Mufti S, Al-Mulla W, Khan MA, Pasca A, Stanway G, Al-Nakib W The Journal of general virology 1990 Sep
External and circadian inputs modulate synaptic protein expression in the visual system of Drosophila melanogaster. Krzeptowski W, Górska-Andrzejak J, Kijak E, Görlich A, Guzik E, Moore G, Pyza EM Frontiers in physiology 2014
Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release. Lee J, Guan Z, Akbergenova Y, Littleton JT The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Jan 2
Drosophila Neto is essential for clustering glutamate receptors at the neuromuscular junction. Kim YJ, Bao H, Bonanno L, Zhang B, Serpe M Genes & development 2012 May 1
Drosophila adducin regulates Dlg phosphorylation and targeting of Dlg to the synapse and epithelial membrane. Wang S, Yang J, Tsai A, Kuca T, Sanny J, Lee J, Dong K, Harden N, Krieger C Developmental biology 2011 Sep 15
Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at single-cell resolution. Chiang AS, Lin CY, Chuang CC, Chang HM, Hsieh CH, Yeh CW, Shih CT, Wu JJ, Wang GT, Chen YC, Wu CC, Chen GY, Ching YT, Lee PC, Lin CY, Lin HH, Wu CC, Hsu HW, Huang YA, Chen JY, Chiang HJ, Lu CF, Ni RF, Yeh CY, Hwang JK Current biology : CB 2011 Jan 11
DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization. Schulte J, Sepp KJ, Jorquera RA, Wu C, Song Y, Hong P, Littleton JT The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Apr 14
Gliotactin and Discs large form a protein complex at the tricellular junction of polarized epithelial cells in Drosophila. Schulte J, Charish K, Que J, Ravn S, MacKinnon C, Auld VJ Journal of cell science 2006 Nov 1
External and circadian inputs modulate synaptic protein expression in the visual system of Drosophila melanogaster. Krzeptowski W, Górska-Andrzejak J, Kijak E, Görlich A, Guzik E, Moore G, Pyza EM Frontiers in physiology 2014
Apical localisation of crumbs in the boundary cells of the Drosophila hindgut is independent of its canonical interaction partner stardust. Kumichel A, Knust E PloS one 2014
Subcellular mapping of dendritic activity in optic flow processing neurons. Hopp E, Borst A, Haag J Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 2014 May
Synaptic abnormalities in a Drosophila model of Alzheimer's disease. Mhatre SD, Satyasi V, Killen M, Paddock BE, Moir RD, Saunders AJ, Marenda DR Disease models & mechanisms 2014 Mar
Loss of the spectraplakin short stop activates the DLK injury response pathway in Drosophila. Valakh V, Walker LJ, Skeath JB, DiAntonio A The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Nov 6
Brain tumor regulates neuromuscular synapse growth and endocytosis in Drosophila by suppressing mad expression. Shi W, Chen Y, Gan G, Wang D, Ren J, Wang Q, Xu Z, Xie W, Zhang YQ The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Jul 24
The kinesin-3, unc-104 regulates dendrite morphogenesis and synaptic development in Drosophila. Kern JV, Zhang YV, Kramer S, Brenman JE, Rasse TM Genetics 2013 Sep
Drosophila cyfip regulates synaptic development and endocytosis by suppressing filamentous actin assembly. Zhao L, Wang D, Wang Q, Rodal AA, Zhang YQ PLoS genetics 2013 Apr
Tuberous sclerosis complex regulates Drosophila neuromuscular junction growth via the TORC2/Akt pathway. Natarajan R, Trivedi-Vyas D, Wairkar YP Human molecular genetics 2013 May 15
Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release. Lee J, Guan Z, Akbergenova Y, Littleton JT The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Jan 2
Neurofibromin mediates FAK signaling in confining synapse growth at Drosophila neuromuscular junctions. Tsai PI, Wang M, Kao HH, Cheng YJ, Walker JA, Chen RH, Chien CT The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Nov 21
Drosophila motor neuron retraction during metamorphosis is mediated by inputs from TGF-β/BMP signaling and orphan nuclear receptors. Boulanger A, Farge M, Ramanoudjame C, Wharton K, Dura JM PloS one 2012
Drosophila Neto is essential for clustering glutamate receptors at the neuromuscular junction. Kim YJ, Bao H, Bonanno L, Zhang B, Serpe M Genes & development 2012 May 1
Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes. Neumüller RA, Wirtz-Peitz F, Lee S, Kwon Y, Buckner M, Hoskins RA, Venken KJ, Bellen HJ, Mohr SE, Perrimon N Genetics 2012 Mar
Stathmin is required for stability of the Drosophila neuromuscular junction. Graf ER, Heerssen HM, Wright CM, Davis GW, DiAntonio A The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Oct 19
Crumbs controls epithelial integrity by inhibiting Rac1 and PI3K. Chartier FJ, Hardy ÉJ, Laprise P Journal of cell science 2011 Oct 15
Drosophila adducin regulates Dlg phosphorylation and targeting of Dlg to the synapse and epithelial membrane. Wang S, Yang J, Tsai A, Kuca T, Sanny J, Lee J, Dong K, Harden N, Krieger C Developmental biology 2011 Sep 15
Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction. Sun M, Xing G, Yuan L, Gan G, Knight D, With SI, He C, Han J, Zeng X, Fang M, Boulianne GL, Xie W The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Jan 12
LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. Lee S, Liu HP, Lin WY, Guo H, Lu B The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Dec 15
Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at single-cell resolution. Chiang AS, Lin CY, Chuang CC, Chang HM, Hsieh CH, Yeh CW, Shih CT, Wu JJ, Wang GT, Chen YC, Wu CC, Chen GY, Ching YT, Lee PC, Lin CY, Lin HH, Wu CC, Hsu HW, Huang YA, Chen JY, Chiang HJ, Lu CF, Ni RF, Yeh CY, Hwang JK Current biology : CB 2011 Jan 11
Three Drosophila liprins interact to control synapse formation. Astigarraga S, Hofmeyer K, Farajian R, Treisman JE The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Nov 17
Formation of a Bazooka-Stardust complex is essential for plasma membrane polarity in epithelia. Krahn MP, Bückers J, Kastrup L, Wodarz A The Journal of cell biology 2010 Sep 6
Involvement of Lgl and Mahjong/VprBP in cell competition. Tamori Y, Bialucha CU, Tian AG, Kajita M, Huang YC, Norman M, Harrison N, Poulton J, Ivanovitch K, Disch L, Liu T, Deng WM, Fujita Y PLoS biology 2010 Jul 13
Retrograde BMP signaling controls synaptic growth at the NMJ by regulating trio expression in motor neurons. Ball RW, Warren-Paquin M, Tsurudome K, Liao EH, Elazzouzi F, Cavanagh C, An BS, Wang TT, White JH, Haghighi AP Neuron 2010 May 27
Drosophila twinfilin is required for cell migration and synaptic endocytosis. Wang D, Zhang L, Zhao G, Wahlström G, Heino TI, Chen J, Zhang YQ Journal of cell science 2010 May 1
DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization. Schulte J, Sepp KJ, Jorquera RA, Wu C, Song Y, Hong P, Littleton JT The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Apr 14
Rab3 dynamically controls protein composition at active zones. Graf ER, Daniels RW, Burgess RW, Schwarz TL, DiAntonio A Neuron 2009 Dec 10
Gliotactin and Discs large form a protein complex at the tricellular junction of polarized epithelial cells in Drosophila. Schulte J, Charish K, Que J, Ravn S, MacKinnon C, Auld VJ Journal of cell science 2006 Nov 1
glaikit is essential for the formation of epithelial polarity and neuronal development. Dunlop J, Morin X, Corominas M, Serras F, Tear G Current biology : CB 2004 Nov 23
Regulation of postsynaptic structure and protein localization by the Rho-type guanine nucleotide exchange factor dPix. Parnas D, Haghighi AP, Fetter RD, Kim SW, Goodman CS Neuron 2001 Nov 8
Congenital corneal anaesthesia and the MURCS association: a case report. Esakowitz L, Yates JR The British journal of ophthalmology 1988 Mar
Detection and differentiation of picornaviruses in clinical samples following genomic amplification. Olive DM, Al-Mufti S, Al-Mulla W, Khan MA, Pasca A, Stanway G, Al-Nakib W The Journal of general virology 1990 Sep