Antibody Name: C17.9C6
Antigen:Notch, intracellular domain
Confocal microscope image of a Drosophila optic lobe labeled with DSHB antibody C17.9C6 (white). PMID: 30794154, Fig. 1B.
Catalog Fields
Identity
Clone ID / Antibody Name: C17.9C6
Alternate Antibody Name: —
Antigen Name: Notch, intracellular domain
Alternate Antigen Name: —
Gene Symbol: —
Gene Name: N
Entrez Gene ID: 31293
Antigen Sequence: —
Antigen Species: Drosophila
Antigen Mol. Weight: Predicted: 289 kDa; Apparent: 300 kDa and C-terminal fragments of 120 kDa and lower MW, resulting from proteolysis.
Uniprot ID: P07207
Human Protein Atlas: —
Antibody Properties
Host Species: Mouse
Clonality: Monoclonal
Isotype: Mouse IgG1, kappa light chain
Myeloma Strain: Ag8
Antibody Registry / RRID: AB_528410
Available to For-Profits: Yes
Hybridoma Available: Yes
Cell lines cannot be distributed to commercial/for-profit users.
Cell lines cannot be distributed to commercial/for-profit users.
Immunogen & Epitope
Immunogen: Recombinant fusion protein containing aa 1791-2504 of the intracellular domain of Notch.
Immunogen Sequence: Partial protein
Epitope Mapped: Yes
Epitope Location / Seq: intracellular domain, aa 1791-2504.
Clone: —
Additional Info: The Neurogenic locus Notch protein functions as a transmembrane receptor for membrane-bound ligands Delta and Serrate to regulate neurodevelopment. Upon ligand activation, the intracellular domain (NICD) is released from the cell membrane, and forms a transcriptional activator complex with the Suppressor of hairless protein.
Add. Characterization: —
Species Reactivity
Confirmed Reactivity: Drosophila
Predicted Reactivity: —
Depositor
Depositor Name: S. Artavanis-Tsakonas
Institution: Harvard Medical School
Deposit Date: May 2, 2000
Depositor Notes: —
Recommended Applications
IF
IHC
IP
WB
Each lab must optimize concentration per application and species. Full usage recommendations →
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