Antibody Name: 10E5
Antigen:integrin alpha IIb
Catalog Fields
Identity
Clone ID / Antibody Name: 10E5
Alternate Antibody Name: —
Antigen Name: integrin alpha IIb
Alternate Antigen Name: —
Gene Symbol: —
Gene Name: ITGA2B
Entrez Gene ID: 3674
Antigen Sequence: —
Antigen Species: human
Antigen Mol. Weight: Predicted: 103, 110, and 113 kDa; Apparent: 140 kDa
Uniprot ID: P17301
Human Protein Atlas: —
Antibody Properties
Host Species: Mouse
Clonality: Monoclonal
Isotype: Mouse IgG2a
Myeloma Strain: X63-Ag8.653
Antibody Registry / RRID: AB_2617389
Available to For-Profits: Yes
Hybridoma Available: No
Immunogen & Epitope
Immunogen: Human platelets
Immunogen Sequence: Full length protein
Epitope Mapped: Yes
Epitope Location / Seq: alpha IIb cap subdomain
Clone: —
Additional Info: 10E5 recognizes the alphaIIb in its native conformation associated to beta3 integrin.
Add. Characterization: —
Species Reactivity
Confirmed Reactivity: Human, Primate
Predicted Reactivity: —
Depositor
Depositor Name: B.S. Coller
Institution: Rockefeller University, Laboratory of Blood and Vascular Biology
Deposit Date: March 3, 2012
Depositor Notes: Inhibits ligand (fibrinogen-von Willebrand factor) binding to integrin alphaIIbbeta3 and platelet aggregation; does not react with platelets of patients with Glanzmann thrombasthenia. This antibody doesn't appear to work for western blotting.
Recommended Applications
ELISA
FACS
Function Blocking
IP
Each lab must optimize concentration per application and species. Full usage recommendations →
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