K87A/10

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SKU: K87A/10

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DSHB Data Sheet

Catalog Fields

Product Name/ID: K87A/10
Available to For-Profits: Yes
Alternate Antibody Name:
Gene Name: Scn8a
Ab Isotype: MIgG1
Gene Symbol:
Antibody Registry ID:  
Uniprot ID: O88420 
RRID:  
Entrez Gene ID: 29710 
Clonality: Monoclonal
Immunogen: GST-fusion protein
Clone:
Immunogen Sequence: a.a. 459-476 (intracellular interdomain loop I-II)
Myeloma Strain: SP2/0
Epitope Mapped: Yes
Antigen Name: Sodium channel protein type 8 subunit alpha (Nav1.6 Na+ channel)
Epitope Location or Sequence: a.a. 459-476
Alternate Antigen Name:
Deposit Date: 2/21/2019
Antigen Molecular Weight: 225.2 kDa (predicted)
Depositor: Trimmer, J.S.
Antigen Sequence:
Depositor Institution: UC - Davis
Antigen Species: Rat
Depositor Notes: K87A/10 does not work well in western blot applications.
Host Species: mouse
Hybridoma Cells Available (Non-Profit): Yes
Confirmed Species Reactivity: Human, Mouse, Rat
Additional Information: K87A/10 specificity has been validated in Nav1.6 null mice. PMID: 19261867.
Predicted Species Reactivity:  
Human Protein Atlas:  
Additional Characterization:  
Recommended Applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation
All cell products contain the antimicrobial ProClin. Click here for additional information.
These hybridomas were created by your colleagues. Please acknowledge the hybridoma contributor and the Developmental Studies Hybridoma Bank (DSHB) in the Materials and Methods of your publications. Please email the citation to us.
For your Materials & Methods section:
K87A/10 was deposited to the DSHB by Trimmer, J.S. (DSHB Hybridoma Product K87A/10)
Storage and Handling Recommendations
Usage Recommendations

6 References

  • Initial Publication
  • IF References
  • IHC References
  • Epitope Map References
  • All References
  • Initial Publication

    Functional specialization of the axon initial segment by isoform-specific sodium channel targeting.
    Matthews G
    The Journal of neuroscience : the official journal of the Society for Neuroscience 23.6 (2003 Mar 15): 2306-13.

    IF References
    IHC References

    Differential modulation of sodium channel Na(v)1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily.
    Waxman SG
    The European journal of neuroscience 23.10 (2006 May): 2551-62.

    Improved Methods for Fluorescence Microscopy Detection of Macromolecules at the Axon Initial Segment.
    Laezza F
    Frontiers in cellular neuroscience 10. (2016): 5.

    Molecular microdomains in a sensory terminal, the vestibular calyx ending.
    Eatock RA
    The Journal of neuroscience : the official journal of the Society for Neuroscience 31.27 (2011 Jul 6): 10101-14.

    Epitope Map References

    Functional specialization of the axon initial segment by isoform-specific sodium channel targeting.
    Matthews G
    The Journal of neuroscience : the official journal of the Society for Neuroscience 23.6 (2003 Mar 15): 2306-13.

    All References

    Differential modulation of sodium channel Na(v)1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily.
    Waxman SG
    The European journal of neuroscience 23.10 (2006 May): 2551-62.

    Improved Methods for Fluorescence Microscopy Detection of Macromolecules at the Axon Initial Segment.
    Laezza F
    Frontiers in cellular neuroscience 10. (2016): 5.

    Molecular microdomains in a sensory terminal, the vestibular calyx ending.
    Eatock RA
    The Journal of neuroscience : the official journal of the Society for Neuroscience 31.27 (2011 Jul 6): 10101-14.

    Functional specialization of the axon initial segment by isoform-specific sodium channel targeting.
    Matthews G
    The Journal of neuroscience : the official journal of the Society for Neuroscience 23.6 (2003 Mar 15): 2306-13.

    Changes in the Fluorescence Tracking of NaV1.6 Protein Expression in a BTBR T+Itpr3tf/J Autistic Mouse Model.
    Alshammari TK
    Neural plasticity 2019. (2019): 4893103.

    Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice.
    Pyott SJ
    Scientific reports 9.1 (2019 Feb 22): 2573.

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