K87A/10
Catalog Fields
Antigen: Sodium channel protein type 8 subunit alpha (Nav1.6 Na+ channel)
Hybridoma Cells Available: Yes
Antigen Species: Rat
Depositor: Trimmer, J.S.
Isotype: MIgG1
Antigen Sequence:
Host Species: mouse
Depositors Institution: UC - Davis
Positive Tested Species Reactivity: Human, Mouse, Rat
Depositors Notes: K87A/10 does not work well in western blot applications.
Predicted Species Reactivity:
Gene: Scn8a
Immunogen: GST-fusion protein
Alternate Gene Names: Nbna1
Alternate Antibody Name:
Clonality: Monoclonal
Alternate Antigen Name:
Epitope Mapped: Yes
Myeloma Strain: SP2/0
Epitope Location or Sequence: a.a. 459-476
Uniprot ID: O88420
Immunogen Sequence: a.a. 459-476 (intracellular interdomain loop I-II)
Entrez Gene ID: 29710
Additional Information: K87A/10 specificity has been validated in Nav1.6 null mice. PMID: 19261867.
Recommended Applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation
These hybridomas were created by your colleagues. Please acknowledge the hybridoma contributor and the Developmental Studies Hybridoma Bank (DSHB) in the Materials and Methods of your publications. Please email the citation to us.
For your Materials & Methods section:
K87A/10 was deposited to the DSHB by Trimmer, J.S. (DSHB Hybridoma Product K87A/10)
Storage and Handling Recommendations
Usage Recommendations
All cell products contain the antimicrobial ProClin. Click here for additional information.
6 References
Initial Publication
Functional specialization of the axon initial segment by isoform-specific sodium channel targeting.
Matthews G
The Journal of neuroscience : the official journal of the Society for Neuroscience 23.6 (2003 Mar 15): 2306-13.