K87A/10

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$45.00 to $425.00
SKU: K87A/10
View product citations for antibody K87A/10 on CiteAb

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Available: 33

DSHB Data Sheet

Catalog Fields

Antigen: Sodium channel protein type 8 subunit alpha (Nav1.6 Na+ channel)
Hybridoma Cells Available: Yes
Antigen Species: Rat
Depositor: Trimmer, J.S.
Isotype: MIgG1
Antigen Sequence:
Host Species: mouse
Depositors Institution: UC - Davis
Positive Tested Species Reactivity: Human, Mouse, Rat
Depositors Notes: K87A/10 does not work well in western blot applications.
Antigen Molecular Weight: 225.2 kDa (predicted)
Human Protein Atlas:  
Predicted Species Reactivity:  
Gene: Scn8a
Immunogen: GST-fusion protein
Alternate Gene Names: Nbna1
Alternate Antibody Name:
Clonality: Monoclonal
Alternate Antigen Name:
Epitope Mapped: Yes
Myeloma Strain: SP2/0
Epitope Location or Sequence: a.a. 459-476
Uniprot ID: O88420 
Immunogen Sequence: a.a. 459-476 (intracellular interdomain loop I-II)
Entrez Gene ID: 29710 
Additional Characterization:  
Antibody Registry ID:  
Additional Information: K87A/10 specificity has been validated in Nav1.6 null mice. PMID: 19261867.
Recommended Applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation
These hybridomas were created by your colleagues. Please acknowledge the hybridoma contributor and the Developmental Studies Hybridoma Bank (DSHB) in the Materials and Methods of your publications. Please email the citation to us.
For your Materials & Methods section:
K87A/10 was deposited to the DSHB by Trimmer, J.S. (DSHB Hybridoma Product K87A/10)
Storage and Handling Recommendations
Usage Recommendations
All cell products contain the antimicrobial ProClin. Click here for additional information.

6 References

  • Initial Publication
  • IF References
  • IHC References
  • Epitope Map References
  • All References
  • Initial Publication

    Functional specialization of the axon initial segment by isoform-specific sodium channel targeting.
    Matthews G
    The Journal of neuroscience : the official journal of the Society for Neuroscience 23.6 (2003 Mar 15): 2306-13.

    IF References
    IHC References

    Differential modulation of sodium channel Na(v)1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily.
    Waxman SG
    The European journal of neuroscience 23.10 (2006 May): 2551-62.

    Improved Methods for Fluorescence Microscopy Detection of Macromolecules at the Axon Initial Segment.
    Laezza F
    Frontiers in cellular neuroscience 10. (2016): 5.

    Molecular microdomains in a sensory terminal, the vestibular calyx ending.
    Eatock RA
    The Journal of neuroscience : the official journal of the Society for Neuroscience 31.27 (2011 Jul 6): 10101-14.

    Epitope Map References

    Functional specialization of the axon initial segment by isoform-specific sodium channel targeting.
    Matthews G
    The Journal of neuroscience : the official journal of the Society for Neuroscience 23.6 (2003 Mar 15): 2306-13.

    All References

    Differential modulation of sodium channel Na(v)1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily.
    Waxman SG
    The European journal of neuroscience 23.10 (2006 May): 2551-62.

    Improved Methods for Fluorescence Microscopy Detection of Macromolecules at the Axon Initial Segment.
    Laezza F
    Frontiers in cellular neuroscience 10. (2016): 5.

    Molecular microdomains in a sensory terminal, the vestibular calyx ending.
    Eatock RA
    The Journal of neuroscience : the official journal of the Society for Neuroscience 31.27 (2011 Jul 6): 10101-14.

    Functional specialization of the axon initial segment by isoform-specific sodium channel targeting.
    Matthews G
    The Journal of neuroscience : the official journal of the Society for Neuroscience 23.6 (2003 Mar 15): 2306-13.

    Changes in the Fluorescence Tracking of NaV1.6 Protein Expression in a BTBR T+Itpr3tf/J Autistic Mouse Model.
    Alshammari TK
    Neural plasticity 2019. (2019): 4893103.

    Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice.
    Pyott SJ
    Scientific reports 9.1 (2019 Feb 22): 2573.

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