poly(GP) TALS 828.179
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Catalog Fields
Clone ID/Product Name: poly(GP) TALS 828.179
Available to For-Profits: Yes
Alternate Antibody Name:
Gene Symbol: C9ORF72
Ab Isotype: MIgG1
Gene Name:
Antibody Registry ID: AB_2753317
Uniprot ID: Q96LT7
Entrez Gene ID: 203228
Clonality: Monoclonal
Immunogen: H2N-C(DPEG4) GPGPGPGPGPGPGPGP
Clone:
Immunogen Sequence: GPGPGPGPGPGPGPGP
Myeloma Strain:
Epitope Mapped: No
Antigen Name: GP dipeptide repeat proteins, poly(GP)
Epitope Location or Sequence:
Alternate Antigen Name:
Deposit Date: 5/3/2018
Antigen Molecular Weight: The molecular weight will depend on the number of GP dipeptide repeats making up the protein.
Depositor: Target ALS Foundation
Antigen Sequence:
Depositor Institution: Target ALS Foundation
Antigen Species: Human
Depositor Notes: This antibody recognizes poly(GP) dipeptide repeat proteins produced from an expanded hexanucleotide (GGGGCC) repeat in the first intron of C9ORF72, the most common known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The expanded GGGGCC repeat undergoes an atypical form of translation - repeat-associated non-ATG (RAN) translation - forming various dipeptide repeat proteins, one of which is poly(GP). The hybridoma was commercially generated with funds from the Target ALS Foundation.
Host Species: Mouse
Hybridoma Cells Available (Non-Profit): Yes
Confirmed Species Reactivity: Human
Additional Information:
Recommended Applications: Immunohistochemistry, Western Blot