poly(GP) TALS 828.179

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SKU: poly(GP) TALS 828.179-s
View product citations for antibody poly(GP) TALS 828.179 on CiteAb

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DSHB Data Sheet

Catalog Fields

Antigen: GP dipeptide repeat proteins, poly(GP)
Hybridoma Cells Available:
Antigen Species: Human
Depositor: Target ALS Foundation
Isotype: MIgG1
Antigen Sequence:
Host Species: mouse
Depositors Institution: Target ALS Foundation
Positive Tested Species Reactivity: Human
Depositors Notes: This antibody recognizes poly(GP) dipeptide repeat proteins produced from an expanded hexanucleotide (GGGGCC) repeat in the first intron of C9ORF72, the most common known genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The expanded GGGGCC repeat undergoes an atypical form of translation - repeat-associated non-ATG (RAN) translation - forming various dipeptide repeat proteins, one of which is poly(GP). The hybridoma was commercially generated with funds from the Target ALS Foundation.
Antigen Molecular Weight: The molecular weight will depend on the number of GP dipeptide repeats making up the protein.
Human Protein Atlas:
Predicted Species Reactivity:  
Gene: C9ORF72
Alternate Gene Names:
Alternate Antibody Name:
Clonality: Monoclonal
Alternate Antigen Name:
Epitope Mapped:
Myeloma Strain:
Epitope Location or Sequence:
Uniprot ID: Q96LT7 
Immunogen Sequence: GPGPGPGPGPGPGPGP
Entrez Gene ID: 203228 
Additional Characterization:
Antibody Registry ID:
Additional Information:
Recommended Applications: Immunohistochemistry, Western Blot
These hybridomas were created by your colleagues. Please acknowledge the hybridoma contributor and the Developmental Studies Hybridoma Bank (DSHB) in the Materials and Methods of your publications. Please email the citation to us.
For your Materials & Methods section:
poly(GP) TALS 828.179 was deposited to the DSHB by Target ALS Foundation (DSHB Hybridoma Product poly(GP) TALS 828.179)
Storage and Handling Recommendations
Although many cell products are maintained at 4°C for years without loss of activity, shelf-life at 4°C is highly variable. To ensure retention of antibody activity, we recommend aliquotting the product into two parts: 1) a volume of antibody stored at 4°C to be used within two weeks. 2) the remaining product diluted with an equal volume of molecular grade glycerol and stored at -20°C.
Usage Recommendations
While optimal Ig concentration for an application will vary, a good starting concentration for immunohistochemistry (IHC), immunofluorescence(IF) and staining is 2-5 µg/ml. For Western blots, the concentration is decreased by one order of magnitude (that is, 0.2-0.5 µg/ml).
All cell products contain the antimicrobial ProClin. Click here for additional information.

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