CH1
Catalog Fields
Clone ID/Product Name: CH1
Available to For-Profits: Yes
Alternate Antibody Name:
Gene Symbol: TPM1
Ab Isotype: MIgG1
Gene Name:
Antibody Registry ID: AB_2205770
Uniprot ID: P04268
Entrez Gene ID: 396366
Clonality: Monoclonal
Immunogen: Purified chicken cardiac muscle tropomyosin
Clone:
Immunogen Sequence: Full length protein
Myeloma Strain: NS1
Epitope Mapped: Yes
Antigen Name: Tropomyosin, alpha-1 chain (striated muscle)
Epitope Location or Sequence: CH1 has been reported to bind to the peptide region encoded by exon 9a of TPM genes [PMID: 24958154]; this exon is well conserved in all vertebrates. But, the binding of CH1 has also been described to be limited to alpha9a [PMID: 22069507].
Alternate Antigen Name:
Deposit Date: 9/8/1988
Antigen Molecular Weight: Apparent: 39 kDa (or smaller depending on the isoform)
Depositor: Lin, J.J.-C.
Antigen Sequence:
Depositor Institution: University of Iowa
Antigen Species: Chicken
Depositor Notes:
Host Species: Mouse
Hybridoma Cells Available (Non-Profit): Yes
Confirmed Species Reactivity: Axolotl, Broad species, Chicken, Fish, Human, Mouse, Rat, Xenopus, Zebrafish
Additional Information: CH1 reacts strongly with striated muscle forms of tropomyosin, including cardiac alpha-tropomyosin and skeletal alpha- and beta-tropomyosins, but not with tropomyosin isoforms from gizzard (smooth muscle) or chicken embryo fibroblasts. CH1 interferes with the binding of tropomyosin to actin. CH1 recognizes sarcomeric Tm soforms alpha-fast, beta, and alpha-slow with poor affinity for alpha-slow.
Recommended Applications: ELISA, FFPE, Function Blocking, Immunofluorescence, Immunoprecipitation, Western Blot