C458.2H
Catalog Fields
Clone ID/Product Name: C458.2H
Available to For-Profits: Yes
Alternate Antibody Name:
Gene Symbol: N
Ab Isotype: MIgG1, kappa light chain
Gene Name:
Entrez Gene ID: 31293
Clonality: Monoclonal
Immunogen: Recombinant fusion protein containing the EGF repeats #12-20
Clone:
Immunogen Sequence: Partial protein
Myeloma Strain: Ag8
Epitope Mapped: Yes
Antigen Name: Notch, extracellular domain, EGF repeats #12-20
Epitope Location or Sequence: extracellular domain, EGF repeats #12-20 [see depositor notes]
Alternate Antigen Name:
Deposit Date: 5/2/2000
Antigen Molecular Weight: Predicted: 289 kDa; Apparent: 300 kDa and lower MW N-terminal fragment, resulting from proteolysis.
Depositor: Artavanis-Tsakonas, S.
Antigen Sequence:
Depositor Institution: Harvard Medical School
Antigen Species: Drosophila
Depositor Notes: This antibody was generated against the extracellular domain of Notch containing the EGF repeats #12-20
Host Species: Mouse
Hybridoma Cells Available (Non-Profit): Yes
Confirmed Species Reactivity: Drosophila
Additional Information: The Neurogenic locus Notch protein functions as a transmembrane receptor for membrane-bound ligands Delta and Serrate to regulate neurodevelopment. Upon ligand activation, the intracellular domain (NICD) is released from the cell membrane, and forms a transcriptional activator complex with the Suppressor of hairless protein.
Recommended Applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot