Clone ID / Name: C458.2H

Anti - Notch, extracellular domain, EGF repeats #12-20

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Immunofluorescent image of a Drosophila embryo cross section labeled with DSHB antibodies C458.2H against Notch, ECD (green) and C594.9B against Delta, ECD (red). PMID: 41683711, Fig. 1B.

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SKU: C458.2H

Product Form :

Supernatant 1.0 ml

~ 42 – 49 μg/mL

Frozen Cells 1 vial

N/A

Growing Cells 1 vial

N/A

iConcentration varies between lots. Lots are distributed in the order they are produced.

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Available: 1

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Catalog Fields

Identity

Clone ID / Name: C458.2H

Alternate Antibody Name: —

Antigen Name: Notch, extracellular domain, EGF repeats #12-20

Alternate Antigen Name: —

Gene Symbol: —

Gene Name: N

Entrez Gene ID: 31293

Antigen Sequence: —

Antigen Species: Drosophila

Antigen Mol. Weight: Predicted: 289 kDa; Apparent: 300 kDa and lower MW N-terminal fragment, resulting from proteolysis.

Uniprot ID: P07207

Human Protein Atlas: —

Antibody Properties

Host Species: Mouse

Clonality: Monoclonal

Isotype: Mouse IgG1, kappa light chain

Myeloma Strain: Ag8

Antibody Registry / RRID: AB_528408

Available to For-Profits: Yes

Hybridoma Available: Yes
Cell lines cannot be distributed to commercial/for-profit users.

Immunogen & Epitope

Immunogen: Recombinant fusion protein containing the EGF repeats #12-20

Immunogen Sequence: Partial protein

Epitope Mapped: Yes

Epitope Location / Seq: extracellular domain, EGF repeats #12-20 [see depositor notes]

Clone: —

Additional Info: The Neurogenic locus Notch protein functions as a transmembrane receptor for membrane-bound ligands Delta and Serrate to regulate neurodevelopment. Upon ligand activation, the intracellular domain (NICD) is released from the cell membrane, and forms a transcriptional activator complex with the Suppressor of hairless protein.

Add. Characterization: —

Species Reactivity

Confirmed Reactivity: Drosophila

Predicted Reactivity: —

Depositor

Depositor Name: S. Artavanis-Tsakonas

Institution: Harvard Medical School

Deposit Date: May 2, 2000

Depositor Notes: This antibody was generated against the extracellular domain of Notch containing the EGF repeats #12-20

Recommended Applications

IHC

Each lab must optimize concentration per application and species. Full usage recommendations →

UniProt DataUniProtP07207 ↗

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Could not load UniProt data for P07207

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Clone ID / Name: C458.2H

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