1D4 anti-Fasciclin II

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$40.00
SKU: 1D4 anti-Fasciclin II
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DSHB Data Sheet

Catalog Fields

Antigen: fasciclin II (Drosophila)
Hybridoma Cells Available: Yes
Antigen Species: Drosophila
Depositor: Goodman, C.
Isotype: MIgG1
Antigen Sequence: 103 a.a. at the intracellular C-terminus
Host Species: mouse
Depositors Institution: University of California, Berkeley
Positive Tested Species Reactivity: Drosophila
Depositors Notes:
Antigen Molecular Weight:
Human Protein Atlas:  
Predicted Species Reactivity:  
Gene: Fas2
Immunogen:
Alternate Gene Names: 1D4; Ab 1D4; anon-EST:Liang-1.60; CG3665; clone 1.60; CT12301; Dmel\CG3665; EG:EG0007.3; Fas; FAS 11; Fas 2; fas II; Fas II; FAS II; fas-II; Fas-II; fas2; FAS2; FascII; fasII; Fasii; FasII; FASII; l(1)G0032; l(1)G0048; l(1)G0081; l(1)G0293; l(1)G0336; mAb 1D4; mAb1D4; mAB1D4; MAB1D4
Alternate Antibody Name:
Clonality: Monoclonal
Alternate Antigen Name:
Epitope Mapped: No
Myeloma Strain: P3 x 63 Ag8.653
Epitope Location or Sequence:
Uniprot ID: P34082 
Immunogen Sequence:
Entrez Gene ID: 31364 
Additional Characterization:  
Antibody Registry ID: AB_528235 
Additional Information: For experiments involving live cells and tissue, 1D4 anti-Fasciclin II supernatant is available without the antimicrobial ProClin. Contact us at 319-335-3826 or dshb@uiowa.edu for special ordering instructions.
Recommended Applications: ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
These hybridomas were created by your colleagues. Please acknowledge the hybridoma contributor and the Developmental Studies Hybridoma Bank (DSHB) in the Materials and Methods of your publications. Please email the citation to us.
For your Materials & Methods section:
1D4 anti-Fasciclin II was deposited to the DSHB by Goodman, C. (DSHB Hybridoma Product 1D4 anti-Fasciclin II)
Storage and Handling Recommendations
Although many cell products are maintained at 4°C for years without loss of activity, shelf-life at 4°C is highly variable. For immediate use, short term storage at 4°C up to two weeks is recommended. For long term storage, divide the solution into volumes of no less than 20 ul for freezing at -20°C or -80°C. The small volume aliquot should provide sufficient reagent for short term use. Freeze-thaw cycles should be avoided. For concentrate or bioreactor products, an equal volume of glycerol, a cryoprotectant, may be added prior to freezing.
Usage Recommendations
Although the optimal Ig concentration for an application varies for each product and must be optimized for each laboratory, a good starting concentration for immunohistochemistry (IHC), immunofluorescence (IF), and immunocytochemistry (ICC) is 2-5 ug/ml. For western blots, the recommended concentration range is 0.2-0.5 ug/ml.
All cell products contain the antimicrobial ProClin. Click here for additional information.

58 References

  • Initial Publication
  • IF References
  • WB References
  • IHC References
  • All References
  • Initial Publication
    IF References

    Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules.
    O'Kane CJ
    Nature neuroscience 10.2 (2007 Feb): 177-85.

    Characterization of the octopaminergic and tyraminergic neurons in the central brain of Drosophila larvae.
    Thum AS
    The Journal of comparative neurology 522.15 (2014 Oct 15): 3485-500.

    Drosophila larvae establish appetitive olfactory memories via mushroom body neurons of embryonic origin.
    Thum AS
    The Journal of neuroscience : the official journal of the Society for Neuroscience 30.32 (2010 Aug 11): 10655-66.

    The role of octopamine and tyramine in Drosophila larval locomotion.
    Thum AS
    The Journal of comparative neurology 520.16 (2012 Nov 1): 3764-85.

    Drosophila amphiphysin functions during synaptic Fasciclin II membrane cycling.
    Budnik V
    The Journal of neuroscience : the official journal of the Society for Neuroscience 23.33 (2003 Nov 19): 10710-6.

    Requirement for a core 1 galactosyltransferase in the Drosophila nervous system.
    Irvine KD
    Developmental dynamics : an official publication of the American Association of Anatomists 237.12 (2008 Dec): 3703-14.

    mummy/cystic encodes an enzyme required for chitin and glycan synthesis, involved in trachea, embryonic cuticle and CNS development--analysis of its role in Drosophila tracheal morphogenesis.
    Casanova J
    Developmental biology 288.1 (2005 Dec 1): 179-93.

    Reception of Slit requires only the chondroitin-sulphate-modified extracellular domain of Syndecan at the target cell surface.
    Vorbrüggen G
    Proceedings of the National Academy of Sciences of the United States of America 106.29 (2009 Jul 21): 11984-8.

    A targeted glycan-related gene screen reveals heparan sulfate proteoglycan sulfation regulates WNT and BMP trans-synaptic signaling.
    Broadie K
    PLoS genetics 8.11 (2012): e1003031.

    Drosophila Ten-m and filamin affect motor neuron growth cone guidance.
    Wides R
    PloS one 6.8 (2011): e22956.

    Visualizing glutamatergic cell bodies and synapses in Drosophila larval and adult CNS.
    DiAntonio A
    The Journal of comparative neurology 508.1 (2008 May 1): 131-52.

    Arborization pattern of engrailed-positive neural lineages reveal neuromere boundaries in the Drosophila brain neuropil.
    Hartenstein V
    The Journal of comparative neurology 517.1 (2009 Nov 1): 87-104.

    Matrix metalloproteinases promote motor axon fasciculation in the Drosophila embryo.
    Broihier HT
    Development (Cambridge, England) 135.1 (2008 Jan): 95-109.

    Synaptic clustering of Fascilin II and Shaker: essential targeting sequences and role of Dlg.
    Isacoff EY
    Neuron 19.5 (1997 Nov): 1007-16.

    Watching a synapse grow: noninvasive confocal imaging of synaptic growth in Drosophila.
    Goodman CS
    Neuron 22.4 (1999 Apr): 719-29.

    Characterization of Drosophila GDNF receptor-like and evidence for its evolutionarily conserved interaction with neural cell adhesion molecule (NCAM)/FasII.
    Saarma M
    PloS one 7.12 (2012): e51997.

    Patterning and organization of motor neuron dendrites in the Drosophila larva.
    Jan YN
    Developmental biology 336.2 (2009 Dec 15): 213-21.

    Population density regulates Drosophila synaptic morphology in a Fasciclin-II-dependent manner.
    McLean JR
    Journal of neurobiology 61.3 (2004 Dec): 392-9.

    Neuroanatomy: brain asymmetry and long-term memory.
    Préat T
    Nature 427.6975 (2004 Feb 12): 605-6.

    Synapse-specific control of synaptic efficacy at the terminals of a single neuron.
    Goodman CS
    Nature 392.6671 (1998 Mar 5): 82-6.

    Genetic analysis of Fasciclin II in Drosophila: defasciculation, refasciculation, and altered fasciculation.
    Goodman CS
    Neuron 13.5 (1994 Nov): 1055-69.

    Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis.
    Riechmann V
    The Journal of cell biology 199.7 (2012 Dec 24): 1131-43.

    Drosophila amyloid precursor protein-like is required for long-term memory.
    Preat T
    The Journal of neuroscience : the official journal of the Society for Neuroscience 31.3 (2011 Jan 19): 1032-7.

    A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms.
    Zipursky SL
    Cell 134.6 (2008 Sep 19): 1007-18.

    Frazzled cytoplasmic P-motifs are differentially required for axon pathway formation in the Drosophila embryonic CNS.
    VanBerkum MF
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 26.7 (2008 Nov): 753-61.

    Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants.
    Restifo LL
    The Journal of neuroscience : the official journal of the Society for Neuroscience 24.25 (2004 Jun 23): 5798-809.

    Early development of the Drosophila brain: III. The pattern of neuropile founder tracts during the larval period.
    Hartenstein V
    The Journal of comparative neurology 455.4 (2003 Jan 20): 417-34.

    Drosophila Dscam is required for divergent segregation of sister branches and suppresses ectopic bifurcation of axons.
    Lee T
    Neuron 33.4 (2002 Feb 14): 559-71.

    Gliolectin-mediated carbohydrate binding at the Drosophila midline ensures the fidelity of axon pathfinding.
    Tiemeyer M
    Development (Cambridge, England) 128.22 (2001 Nov): 4585-95.

    Homeostatic control of presynaptic release is triggered by postsynaptic membrane depolarization.
    Davis GW
    Neuron 30.3 (2001 Jun): 737-49.

    Protein O-Mannosyltransferases Affect Sensory Axon Wiring and Dynamic Chirality of Body Posture in the <i>Drosophila</i> Embryo.
    Panin VM
    The Journal of neuroscience : the official journal of the Society for Neuroscience 38.7 (2018 Feb 14): 1850-1865.

    A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities.
    Yamaguchi M
    Experimental cell research 362.2 (2018 Jan 15): 461-471.

    Characterization of the octopaminergic and tyraminergic neurons in the central brain of Drosophila larvae.
    Thum AS
    The Journal of comparative neurology 522.15 (2014 Oct 15): 3485-500.

    Neuropeptide F neurons modulate sugar reward during associative olfactory learning of Drosophila larvae.
    Thum AS
    The Journal of comparative neurology 523.18 (2015 Dec 15): 2637-64.

    cGMP-Dependent Protein Kinase Encoded by foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function.
    Liu L
    The Journal of neuroscience : the official journal of the Society for Neuroscience 36.16 (2016 Apr 20): 4635-46.

    Dendritic diversification through transcription factor-mediated suppression of alternative morphologies.
    Grueber WB
    Development (Cambridge, England) 143.8 (2016 Apr 15): 1351-62.

    The transcription factor SoxD controls neuronal guidance in the Drosophila visual system.
    Oliva C
    Scientific reports 8.1 (2018 Sep 6): 13332.

    Reproduction disrupts stem cell homeostasis in testes of aged male Drosophila via an induced microenvironment.
    Pi H
    PLoS genetics 15.7 (2019 Jul): e1008062.

    WB References
    IHC References

    Echinoid facilitates Notch pathway signalling during Drosophila neurogenesis through functional interaction with Delta.
    Jarman AP
    Development (Cambridge, England) 130.26 (2003 Dec): 6475-84.

    The Drosophila larval visual system: high-resolution analysis of a simple visual neuropil.
    Hartenstein V
    Developmental biology 358.1 (2011 Oct 1): 33-43.

    The F-actin-microtubule crosslinker Shot is a platform for Krasavietz-mediated translational regulation of midline axon repulsion.
    Lee S
    Development (Cambridge, England) 134.9 (2007 May): 1767-77.

    The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance.
    Van Vactor D
    Neuron 42.6 (2004 Jun 24): 913-26.

    Long disordered regions of the C-terminal domain of Abelson tyrosine kinase have specific and additive functions in regulation and axon localization.
    VanBerkum MFA
    PloS one 12.12 (2017): e0189338.

    Dendritic diversification through transcription factor-mediated suppression of alternative morphologies.
    Grueber WB
    Development (Cambridge, England) 143.8 (2016 Apr 15): 1351-62.

    Learning a Spatial Task by Trial and Error in Drosophila.
    Yang CH
    Current biology : CB 29.15 (2019 Aug 5): 2517-2525.e5.

    Homeodomain-interacting protein kinase (Hipk) plays roles in nervous system and muscle structure and function.
    Verheyen EM
    PloS one 15.3 (2020): e0221006.

    CAMIO: a transgenic CRISPR pipeline to create diverse targeted genome deletions in Drosophila.
    Lee T
    Nucleic acids research 48.8 (2020 May 7): 4344-4356.

    Developmental axon regrowth and primary neuron sprouting utilize distinct actin elongation factors.
    Schuldiner O
    The Journal of cell biology 219.5 (2020 May 4): .

    Visualization of Endogenous Type I TGF-β Receptor Baboon in the Drosophila Brain.
    Yu HH
    Scientific reports 10.1 (2020 Mar 20): 5132.

    All References

    Echinoid facilitates Notch pathway signalling during Drosophila neurogenesis through functional interaction with Delta.
    Jarman AP
    Development (Cambridge, England) 130.26 (2003 Dec): 6475-84.

    The Drosophila larval visual system: high-resolution analysis of a simple visual neuropil.
    Hartenstein V
    Developmental biology 358.1 (2011 Oct 1): 33-43.

    The F-actin-microtubule crosslinker Shot is a platform for Krasavietz-mediated translational regulation of midline axon repulsion.
    Lee S
    Development (Cambridge, England) 134.9 (2007 May): 1767-77.

    The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance.
    Van Vactor D
    Neuron 42.6 (2004 Jun 24): 913-26.

    Long disordered regions of the C-terminal domain of Abelson tyrosine kinase have specific and additive functions in regulation and axon localization.
    VanBerkum MFA
    PloS one 12.12 (2017): e0189338.

    Dendritic diversification through transcription factor-mediated suppression of alternative morphologies.
    Grueber WB
    Development (Cambridge, England) 143.8 (2016 Apr 15): 1351-62.

    Learning a Spatial Task by Trial and Error in Drosophila.
    Yang CH
    Current biology : CB 29.15 (2019 Aug 5): 2517-2525.e5.

    Homeodomain-interacting protein kinase (Hipk) plays roles in nervous system and muscle structure and function.
    Verheyen EM
    PloS one 15.3 (2020): e0221006.

    CAMIO: a transgenic CRISPR pipeline to create diverse targeted genome deletions in Drosophila.
    Lee T
    Nucleic acids research 48.8 (2020 May 7): 4344-4356.

    Developmental axon regrowth and primary neuron sprouting utilize distinct actin elongation factors.
    Schuldiner O
    The Journal of cell biology 219.5 (2020 May 4): .

    Visualization of Endogenous Type I TGF-β Receptor Baboon in the Drosophila Brain.
    Yu HH
    Scientific reports 10.1 (2020 Mar 20): 5132.

    Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules.
    O'Kane CJ
    Nature neuroscience 10.2 (2007 Feb): 177-85.

    Characterization of the octopaminergic and tyraminergic neurons in the central brain of Drosophila larvae.
    Thum AS
    The Journal of comparative neurology 522.15 (2014 Oct 15): 3485-500.

    Drosophila larvae establish appetitive olfactory memories via mushroom body neurons of embryonic origin.
    Thum AS
    The Journal of neuroscience : the official journal of the Society for Neuroscience 30.32 (2010 Aug 11): 10655-66.

    The role of octopamine and tyramine in Drosophila larval locomotion.
    Thum AS
    The Journal of comparative neurology 520.16 (2012 Nov 1): 3764-85.

    Drosophila amphiphysin functions during synaptic Fasciclin II membrane cycling.
    Budnik V
    The Journal of neuroscience : the official journal of the Society for Neuroscience 23.33 (2003 Nov 19): 10710-6.

    Requirement for a core 1 galactosyltransferase in the Drosophila nervous system.
    Irvine KD
    Developmental dynamics : an official publication of the American Association of Anatomists 237.12 (2008 Dec): 3703-14.

    mummy/cystic encodes an enzyme required for chitin and glycan synthesis, involved in trachea, embryonic cuticle and CNS development--analysis of its role in Drosophila tracheal morphogenesis.
    Casanova J
    Developmental biology 288.1 (2005 Dec 1): 179-93.

    Reception of Slit requires only the chondroitin-sulphate-modified extracellular domain of Syndecan at the target cell surface.
    Vorbrüggen G
    Proceedings of the National Academy of Sciences of the United States of America 106.29 (2009 Jul 21): 11984-8.

    A targeted glycan-related gene screen reveals heparan sulfate proteoglycan sulfation regulates WNT and BMP trans-synaptic signaling.
    Broadie K
    PLoS genetics 8.11 (2012): e1003031.

    Drosophila Ten-m and filamin affect motor neuron growth cone guidance.
    Wides R
    PloS one 6.8 (2011): e22956.

    Visualizing glutamatergic cell bodies and synapses in Drosophila larval and adult CNS.
    DiAntonio A
    The Journal of comparative neurology 508.1 (2008 May 1): 131-52.

    Arborization pattern of engrailed-positive neural lineages reveal neuromere boundaries in the Drosophila brain neuropil.
    Hartenstein V
    The Journal of comparative neurology 517.1 (2009 Nov 1): 87-104.

    Matrix metalloproteinases promote motor axon fasciculation in the Drosophila embryo.
    Broihier HT
    Development (Cambridge, England) 135.1 (2008 Jan): 95-109.

    Synaptic clustering of Fascilin II and Shaker: essential targeting sequences and role of Dlg.
    Isacoff EY
    Neuron 19.5 (1997 Nov): 1007-16.

    Watching a synapse grow: noninvasive confocal imaging of synaptic growth in Drosophila.
    Goodman CS
    Neuron 22.4 (1999 Apr): 719-29.

    Characterization of Drosophila GDNF receptor-like and evidence for its evolutionarily conserved interaction with neural cell adhesion molecule (NCAM)/FasII.
    Saarma M
    PloS one 7.12 (2012): e51997.

    Patterning and organization of motor neuron dendrites in the Drosophila larva.
    Jan YN
    Developmental biology 336.2 (2009 Dec 15): 213-21.

    Population density regulates Drosophila synaptic morphology in a Fasciclin-II-dependent manner.
    McLean JR
    Journal of neurobiology 61.3 (2004 Dec): 392-9.

    Neuroanatomy: brain asymmetry and long-term memory.
    Préat T
    Nature 427.6975 (2004 Feb 12): 605-6.

    Synapse-specific control of synaptic efficacy at the terminals of a single neuron.
    Goodman CS
    Nature 392.6671 (1998 Mar 5): 82-6.

    Genetic analysis of Fasciclin II in Drosophila: defasciculation, refasciculation, and altered fasciculation.
    Goodman CS
    Neuron 13.5 (1994 Nov): 1055-69.

    Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis.
    Riechmann V
    The Journal of cell biology 199.7 (2012 Dec 24): 1131-43.

    Drosophila amyloid precursor protein-like is required for long-term memory.
    Preat T
    The Journal of neuroscience : the official journal of the Society for Neuroscience 31.3 (2011 Jan 19): 1032-7.

    A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms.
    Zipursky SL
    Cell 134.6 (2008 Sep 19): 1007-18.

    Frazzled cytoplasmic P-motifs are differentially required for axon pathway formation in the Drosophila embryonic CNS.
    VanBerkum MF
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 26.7 (2008 Nov): 753-61.

    Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants.
    Restifo LL
    The Journal of neuroscience : the official journal of the Society for Neuroscience 24.25 (2004 Jun 23): 5798-809.

    Early development of the Drosophila brain: III. The pattern of neuropile founder tracts during the larval period.
    Hartenstein V
    The Journal of comparative neurology 455.4 (2003 Jan 20): 417-34.

    Drosophila Dscam is required for divergent segregation of sister branches and suppresses ectopic bifurcation of axons.
    Lee T
    Neuron 33.4 (2002 Feb 14): 559-71.

    Gliolectin-mediated carbohydrate binding at the Drosophila midline ensures the fidelity of axon pathfinding.
    Tiemeyer M
    Development (Cambridge, England) 128.22 (2001 Nov): 4585-95.

    Homeostatic control of presynaptic release is triggered by postsynaptic membrane depolarization.
    Davis GW
    Neuron 30.3 (2001 Jun): 737-49.

    Protein O-Mannosyltransferases Affect Sensory Axon Wiring and Dynamic Chirality of Body Posture in the <i>Drosophila</i> Embryo.
    Panin VM
    The Journal of neuroscience : the official journal of the Society for Neuroscience 38.7 (2018 Feb 14): 1850-1865.

    A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities.
    Yamaguchi M
    Experimental cell research 362.2 (2018 Jan 15): 461-471.

    Neuropeptide F neurons modulate sugar reward during associative olfactory learning of Drosophila larvae.
    Thum AS
    The Journal of comparative neurology 523.18 (2015 Dec 15): 2637-64.

    cGMP-Dependent Protein Kinase Encoded by foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function.
    Liu L
    The Journal of neuroscience : the official journal of the Society for Neuroscience 36.16 (2016 Apr 20): 4635-46.

    The transcription factor SoxD controls neuronal guidance in the Drosophila visual system.
    Oliva C
    Scientific reports 8.1 (2018 Sep 6): 13332.

    Reproduction disrupts stem cell homeostasis in testes of aged male Drosophila via an induced microenvironment.
    Pi H
    PLoS genetics 15.7 (2019 Jul): e1008062.

    Genetic analysis of growth cone guidance in Drosophila: fasciclin II functions as a neuronal recognition molecule.
    Goodman CS
    Cell 67.1 (1991 Oct 4): 45-57.

    Drosophila fasciclinII is required for the formation of odor memories and for normal sensitivity to alcohol.
    Davis RL
    Cell 105.6 (2001 Jun 15): 757-68.

    Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development.
    Klämbt C
    Neuron 26.2 (2000 May): 357-70.

    MicroRNA-8 promotes robust motor axon targeting by coordinate regulation of cell adhesion molecules during synapse development.
    Van Vactor D
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences 369.1652 (2014 Sep 26): .

    Neurotransmitter-induced changes in the intracellular calcium concentration suggest a differential central modulation of CCAP neuron subsets in Drosophila.
    Wegener C
    Developmental neurobiology 67.6 (2007 May): 792-808.

    Photoreceptor neurons find new synaptic targets when misdirected by overexpressing runt in Drosophila.
    Meinertzhagen IA
    The Journal of neuroscience : the official journal of the Society for Neuroscience 29.3 (2009 Jan 21): 828-41.

    Genetic ablation of Drosophila phagocytes reveals their contribution to both development and resistance to bacterial infection.
    Leulier F
    Journal of innate immunity 1.4 (2009): 322-34.

    Interdependence of macrophage migration and ventral nerve cord development in Drosophila embryos.
    Wood W
    Development (Cambridge, England) 137.10 (2010 May): 1625-33.

    Atypical cadherins Dachsous and Fat control dynamics of noncentrosomal microtubules in planar cell polarity.
    Uemura T
    Developmental cell 19.3 (2010 Sep 14): 389-401.

    Developmental changes in expression, subcellular distribution, and function of Drosophila N-cadherin, guided by a cell-intrinsic program during neuronal differentiation.
    Suzuki E
    Developmental biology 366.2 (2012 Jun 15): 204-17.

    Regulation of Fasciclin II and synaptic terminal development by the splicing factor beag.
    McCabe BD
    The Journal of neuroscience : the official journal of the Society for Neuroscience 32.20 (2012 May 16): 7058-73.

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