SV2

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$40.00
SKU: SV2
View product citations for antibody SV2 on CiteAb

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DSHB Data Sheet

Catalog Fields

Antigen: Synaptic vesicle glycoprotein 2A; synaptic vesicles
Hybridoma Cells Available: Yes
Antigen Species: Ommata
Depositor: Buckley, K.M.
Isotype: MIgG1
Antigen Sequence:
Host Species: mouse
Depositors Institution: Harvard Medical School
Positive Tested Species Reactivity: Avian, Bovine, Fish, Human, Mouse, Planaria, Primate, Rat, Xenopus, Zebrafish
Depositors Notes: This antibody recognizes all three isoforms: SV2A, SV2B and SV2C.
Antigen Molecular Weight: 95 kDa
Human Protein Atlas:
Predicted Species Reactivity:  
Gene: SV2A
Immunogen: Purified synaptic vesicles
Alternate Gene Names:
Alternate Antibody Name:
Clonality: Monoclonal
Alternate Antigen Name:
Epitope Mapped:
Myeloma Strain: SP2/0
Epitope Location or Sequence:
Uniprot ID: Q7L0J3 
Immunogen Sequence:
Entrez Gene ID: 9900 
Additional Characterization:
Antibody Registry ID: AB_2315387 
Additional Information: recognizes all 3 isoforms, SV2A, B & C
Recommended Applications: Immunofluorescence, Immunohistochemistry, Western Blot
These hybridomas were created by your colleagues. Please acknowledge the hybridoma contributor and the Developmental Studies Hybridoma Bank (DSHB) in the Materials and Methods of your publications. Please email the citation to us.
For your Materials & Methods section:
SV2 was deposited to the DSHB by Buckley, K.M. (DSHB Hybridoma Product SV2)
Storage and Handling Recommendations
Although many cell products are maintained at 4°C for years without loss of activity, shelf-life at 4°C is highly variable. To ensure retention of antibody activity, we recommend aliquotting the product into two parts: 1) a volume of antibody stored at 4°C to be used within two weeks. 2) the remaining product diluted with an equal volume of molecular grade glycerol and stored at -20°C.
Usage Recommendations
While optimal Ig concentration for an application will vary, a good starting concentration for immunohistochemistry (IHC), immunofluorescence(IF) and staining is 2-5 µg/ml. For Western blots, the concentration is decreased by one order of magnitude (that is, 0.2-0.5 µg/ml).
All cell products contain the antimicrobial ProClin. Click here for additional information.

29 References

  • Initial Publication
  • IF References
  • WB References
  • IHC References
  • IP References
  • All References
  • Initial Publication
    IF References

    Localization of Cadm2a and Cadm3 proteins during development of the zebrafish nervous system.
    Meyer MP
    The Journal of comparative neurology 519.11 (2011 Aug 1): 2252-70.

    The role of muscle microRNAs in repairing the neuromuscular junction.
    Sanes JR
    PloS one 9.3 (2014): e93140.

    A stem-cell based bioassay to critically assess the pathology of dysfunctional neuromuscular junctions.
    Rafuse VF
    PloS one 9.3 (2014): e91643.

    Early development of the gonadotropin-releasing hormone neuronal network in transgenic zebrafish.
    Wayne NL
    Frontiers in endocrinology 4. (2013): 107.

    α2-Chimaerin regulates a key axon guidance transition during development of the oculomotor projection.
    Guthrie S
    The Journal of neuroscience : the official journal of the Society for Neuroscience 33.42 (2013 Oct 16): 16540-51.

    Wide-field diffuse amacrine cells in the monkey retina contain immunoreactive Cocaine- and Amphetamine-Regulated Transcript (CART).
    Marshak DW
    Peptides 84. (2016 Oct): 22-35.

    Cross-disease comparison of amyotrophic lateral sclerosis and spinal muscular atrophy reveals conservation of selective vulnerability but differential neuromuscular junction pathology.
    Hedlund E
    The Journal of comparative neurology 524.7 (2016 May 1): 1424-42.

    Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation.
    Morgan JR
    Molecular biology of the cell 25.24 (2014 Dec 1): 3926-41.

    Cyclic AMP promotes axon regeneration, lesion repair and neuronal survival in lampreys after spinal cord injury.
    Morgan JR
    Experimental neurology 250. (2013 Dec): 31-42.

    Synuclein accumulation is associated with cell-specific neuronal death after spinal cord injury.
    Morgan JR
    The Journal of comparative neurology 520.8 (2012 Jun 1): 1751-71.

    Increased synapsin expression and neurite sprouting in lamprey brain after spinal cord injury.
    Morgan JR
    Experimental neurology 228.2 (2011 Apr): 283-93.

    Regenerated synapses in lamprey spinal cord are sparse and small even after functional recovery from injury.
    Morgan JR
    The Journal of comparative neurology 518.14 (2010 Jul 15): 2854-72.

    DHTKD1 Deficiency Causes Charcot-Marie-Tooth Disease in Mice.
    Wang ZG
    Molecular and cellular biology 38.13 (2018 Jul 1): .

    Neuromuscular Disease Models and Analysis.
    Seburn KL
    Methods in molecular biology (Clifton, N.J.) 1438. (2016): 349-94.

    Calotropis gigantea Promotes Neuritogenesis and Synaptogenesis through Activation of NGF-TrkA-Erk1/2 Signaling in Rat Hippocampal Neurons.
    Moon IS
    The American journal of Chinese medicine 46.8 (2018): 1861-1877.

    Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons.
    Almeida RD
    Cell reports 28.4 (2019 Jul 23): 864-876.e6.

    NAD+ improves neuromuscular development in a zebrafish model of FKRP-associated dystroglycanopathy.
    Henry CA
    Skeletal muscle 9.1 (2019 Aug 7): 21.

    WB References
    IHC References

    Molecular dynamics of photoreceptor synapse formation in the developing chick retina.
    Adler R
    The Journal of comparative neurology 506.5 (2008 Feb 10): 822-37.

    Tcf7l2 is required for left-right asymmetric differentiation of habenular neurons.
    Carl M
    Current biology : CB 24.19 (2014 Oct 6): 2217-27.

    Neurochemical anatomy of the zebrafish retina as determined by immunocytochemistry.
    Studholme KM
    Journal of neurocytology 30.7 (2001 Jul): 551-92.

    Rapid and continuous activity-dependent plasticity of olfactory sensory input.
    Belluscio L
    Nature communications 7. (2016 Feb 22): 10729.

    Neuronal labeling patterns in the spinal cord of adult transgenic Zebrafish.
    Drapeau P
    Developmental neurobiology 76.6 (2016 Jun): 642-60.

    IP References

    The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam.
    Fuks B
    Proceedings of the National Academy of Sciences of the United States of America 101.26 (2004 Jun 29): 9861-6.

    All References

    Molecular dynamics of photoreceptor synapse formation in the developing chick retina.
    Adler R
    The Journal of comparative neurology 506.5 (2008 Feb 10): 822-37.

    Tcf7l2 is required for left-right asymmetric differentiation of habenular neurons.
    Carl M
    Current biology : CB 24.19 (2014 Oct 6): 2217-27.

    Neurochemical anatomy of the zebrafish retina as determined by immunocytochemistry.
    Studholme KM
    Journal of neurocytology 30.7 (2001 Jul): 551-92.

    Rapid and continuous activity-dependent plasticity of olfactory sensory input.
    Belluscio L
    Nature communications 7. (2016 Feb 22): 10729.

    Neuronal labeling patterns in the spinal cord of adult transgenic Zebrafish.
    Drapeau P
    Developmental neurobiology 76.6 (2016 Jun): 642-60.

    Localization of Cadm2a and Cadm3 proteins during development of the zebrafish nervous system.
    Meyer MP
    The Journal of comparative neurology 519.11 (2011 Aug 1): 2252-70.

    The role of muscle microRNAs in repairing the neuromuscular junction.
    Sanes JR
    PloS one 9.3 (2014): e93140.

    A stem-cell based bioassay to critically assess the pathology of dysfunctional neuromuscular junctions.
    Rafuse VF
    PloS one 9.3 (2014): e91643.

    Early development of the gonadotropin-releasing hormone neuronal network in transgenic zebrafish.
    Wayne NL
    Frontiers in endocrinology 4. (2013): 107.

    α2-Chimaerin regulates a key axon guidance transition during development of the oculomotor projection.
    Guthrie S
    The Journal of neuroscience : the official journal of the Society for Neuroscience 33.42 (2013 Oct 16): 16540-51.

    Wide-field diffuse amacrine cells in the monkey retina contain immunoreactive Cocaine- and Amphetamine-Regulated Transcript (CART).
    Marshak DW
    Peptides 84. (2016 Oct): 22-35.

    Cross-disease comparison of amyotrophic lateral sclerosis and spinal muscular atrophy reveals conservation of selective vulnerability but differential neuromuscular junction pathology.
    Hedlund E
    The Journal of comparative neurology 524.7 (2016 May 1): 1424-42.

    Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation.
    Morgan JR
    Molecular biology of the cell 25.24 (2014 Dec 1): 3926-41.

    Cyclic AMP promotes axon regeneration, lesion repair and neuronal survival in lampreys after spinal cord injury.
    Morgan JR
    Experimental neurology 250. (2013 Dec): 31-42.

    Synuclein accumulation is associated with cell-specific neuronal death after spinal cord injury.
    Morgan JR
    The Journal of comparative neurology 520.8 (2012 Jun 1): 1751-71.

    Increased synapsin expression and neurite sprouting in lamprey brain after spinal cord injury.
    Morgan JR
    Experimental neurology 228.2 (2011 Apr): 283-93.

    Regenerated synapses in lamprey spinal cord are sparse and small even after functional recovery from injury.
    Morgan JR
    The Journal of comparative neurology 518.14 (2010 Jul 15): 2854-72.

    DHTKD1 Deficiency Causes Charcot-Marie-Tooth Disease in Mice.
    Wang ZG
    Molecular and cellular biology 38.13 (2018 Jul 1): .

    Neuromuscular Disease Models and Analysis.
    Seburn KL
    Methods in molecular biology (Clifton, N.J.) 1438. (2016): 349-94.

    Calotropis gigantea Promotes Neuritogenesis and Synaptogenesis through Activation of NGF-TrkA-Erk1/2 Signaling in Rat Hippocampal Neurons.
    Moon IS
    The American journal of Chinese medicine 46.8 (2018): 1861-1877.

    Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons.
    Almeida RD
    Cell reports 28.4 (2019 Jul 23): 864-876.e6.

    NAD+ improves neuromuscular development in a zebrafish model of FKRP-associated dystroglycanopathy.
    Henry CA
    Skeletal muscle 9.1 (2019 Aug 7): 21.

    Synaptic vesicle protein 2 binds adenine nucleotides.
    Bajjalieh SM
    The Journal of biological chemistry 283.30 (2008 Jul 25): 20628-34.

    Association of botulinum neurotoxin serotypes a and B with synaptic vesicle protein complexes.
    Barbieri JT
    Biochemistry 46.11 (2007 Mar 20): 3200-10.

    Extensive growth is followed by neurodegenerative pathology in the continuously expanding adult zebrafish retina.
    Moons L
    Biogerontology 20.1 (2019 Feb): 109-125.

    Mesenchymal Stem Cells Therapy Improved the Streptozotocin-Induced Behavioral and Hippocampal Impairment in Rats.
    Reggiani PC
    Molecular neurobiology . (2019 Aug 10): .

    The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam.
    Fuks B
    Proceedings of the National Academy of Sciences of the United States of America 101.26 (2004 Jun 29): 9861-6.

    Identification of a transmembrane glycoprotein specific for secretory vesicles of neural and endocrine cells.
    Kelly RB
    The Journal of cell biology 100.4 (1985 Apr): 1284-94.

    Winning with political action; influencing health care policy.
    Curtis B
    Washington State journal of nursing 51.2 (1979 Summer-Fall): 17-24.

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