Math1 (Atoh1)

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SKU: Math1 (Atoh1)

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DSHB Data Sheet

Catalog Fields

Product Name/ID: Math1 (Atoh1)
Available to For-Profits: Yes
Alternate Antibody Name: Atoh1
Gene Name: Atoh1
Ab Isotype: MIgG1, kappa light chain
Gene Symbol:
Antibody Registry ID: AB_10805299 
Uniprot ID: P48985 
Entrez Gene ID: 11921 
Clonality: Monoclonal
Immunogen: Rcombinant Math1/GST fusion protein
Immunogen Sequence: Full length protein
Myeloma Strain:
Epitope Mapped: No
Antigen Name: Math1 (Atoh1)
Epitope Location or Sequence:
Alternate Antigen Name:
Deposit Date: 7/25/2002
Antigen Molecular Weight: Predicted: 38 kDa
Depositor: Johnson, J.
Antigen Sequence:
Depositor Institution: UT Southwestern Medical Center
Antigen Species: Mouse
Depositor Notes: Doesn't work on Chicken. Expression in neuronal progenitor cells in dorsal neural tube, EGL of cerebellum, hair cells in inner ear, Merkel cells in skin. Doesn't appear to have a functional effect.
Host Species: mouse
Hybridoma Cells Available (Non-Profit): Yes
Confirmed Species Reactivity: Mouse
Additional Information:
Predicted Species Reactivity:  
Human Protein Atlas:  
Additional Characterization:  
Recommended Applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
All cell products contain the antimicrobial ProClin. Click here for additional information.
These hybridomas were created by your colleagues. Please acknowledge the hybridoma contributor and the Developmental Studies Hybridoma Bank (DSHB) in the Materials and Methods of your publications. Please email the citation to us.
For your Materials & Methods section:
Math1 (Atoh1) was deposited to the DSHB by Johnson, J. (DSHB Hybridoma Product Math1 (Atoh1))
Storage and Handling Recommendations
Although many cell products are maintained at 4°C for years without loss of activity, shelf-life at 4°C is highly variable. For immediate use, short term storage at 4°C up to two weeks is recommended. For long term storage, divide the solution into volumes of no less than 20 ul for freezing at -20°C or -80°C. The small volume aliquot should provide sufficient reagent for short term use. Freeze-thaw cycles should be avoided. For concentrate or bioreactor products, an equal volume of glycerol, a cryoprotectant, may be added prior to freezing.
Usage Recommendations
The optimal Ig concentration for an application varies by species and antibody affinity. For each product, the antibody titer must be optimized for every application by the end user laboratory. A good starting concentration for immunohistochemistry (IHC), immunofluorescence (IF), and immunocytochemistry (ICC) when using mouse Ig is 2-5 ug/ml. For western blots, the recommended concentration range of mouse Ig 0.2-0.5 ug/ml. In general, rabbit antibodies demonstrate greater affinity and are used at a magnitude lower Ig concentration for initial testing. The recommended concentrations for rabbit Ig are 0.2-0.5 ug/ml (IF, IHC and ICC) and 20-50 ng/ml (WB).

12 References

  • Initial Publication
  • IF References
  • WB References
  • IHC References
  • FFPE References
  • All References
  • Initial Publication

    Expression of Notch1 and Math1 in mandibular condyle cartilage in neonatal mice.
    Kawakami T
    The Angle orthodontist 75.6 (2005 Nov): 993-5.

    IF References
    WB References
    IHC References
    FFPE References
    All References

    Expression of Notch1 and Math1 in mandibular condyle cartilage in neonatal mice.
    Kawakami T
    The Angle orthodontist 75.6 (2005 Nov): 993-5.

    Lateral line placodes of aquatic vertebrates are evolutionarily conserved in mammals.
    Knabe W
    Biology open 7.6 (2018 Jun 19): .

    The roof plate regulates cerebellar cell-type specification and proliferation.
    Millen KJ
    Development (Cambridge, England) 133.15 (2006 Aug): 2793-804.

    Generation of cerebellar neuron precursors from embryonic stem cells.
    Sasai Y
    Developmental biology 290.2 (2006 Feb 15): 287-96.

    Ric-8a, a guanine nucleotide exchange factor for heterotrimeric G proteins, regulates bergmann glia-basement membrane adhesion during cerebellar foliation.
    Huang Z
    The Journal of neuroscience : the official journal of the Society for Neuroscience 32.43 (2012 Oct 24): 14979-93.

    Epigenetic DNA Demethylation Causes Inner Ear Stem Cell Differentiation into Hair Cell-Like Cells.
    Hu Z
    Frontiers in cellular neuroscience 10. (2016): 185.

    Msx1 and Msx2 act as essential activators of Atoh1 expression in the murine spinal cord.
    Robert B
    Development (Cambridge, England) 141.8 (2014 Apr): 1726-36.

    Environmental cues from CNS, PNS, and ENS cells regulate CNS progenitor differentiation.
    Fex Svenningsen A
    Neuroreport 19.13 (2008 Aug 27): 1283-9.

    Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum.
    Ogawa M
    Neural development 5. (2010 Sep 1): 23.

    Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation.
    Ayrault O
    Developmental cell 48.2 (2019 Jan 28): 184-199.e5.

    Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma.
    Roussel MF
    Molecular cancer research : MCR 7.1 (2009 Jan): 33-40.

    The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development.
    McMahon AP
    Genes & development 21.10 (2007 May 15): 1244-57.

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