PY489-B-catenin
Catalog Fields
Clone ID/Product Name: PY489-B-catenin
Available to For-Profits: Yes
Alternate Antibody Name: PY489
Gene Symbol: Ctnnb1
Ab Isotype: MIgM
Gene Name:
Antibody Registry ID: AB_10144551
Uniprot ID: Q02248
Entrez Gene ID: 12387
Clonality: Monoclonal
Immunogen: synthetic phospho-peptide
Clone:
Immunogen Sequence: NH2-CRHQEAEMAQNAVRLHpYGL-OH
Myeloma Strain: SP2/0
Epitope Mapped: Yes
Antigen Name: catenin, beta-
Epitope Location or Sequence: NH2-CRHQEAEMAQNAVRLHpYGL-OH
Alternate Antigen Name:
Deposit Date: 6/28/2007
Antigen Molecular Weight: Predicted: 85kDa
Depositor: Balsamo, J. / Lilien, J.
Antigen Sequence:
Depositor Institution: University of Iowa
Antigen Species: Mouse
Depositor Notes: Fusion: 09/05.
Host Species: Mouse
Hybridoma Cells Available (Non-Profit): Yes
Confirmed Species Reactivity: Canine, Chicken, Mouse
Additional Information: This antibody is specific to beta-catenin phosphorylated at Tyr 489. Beta-1 Catenin is a Key downstream component of the canonical Wnt signaling pathway whose function is affected by differential phosphorylation. Specificity tested on Y489F beta-catenin. See mAb PY654-B-catenin (IgG) for an antibody specific to beta-catenin phosphorylated at Tyr 654. The catenin target of PY489-B-catenin has been described as nuclear-bound/active beta-catenin, and the target of PY654-B-catenin (IgG) has been described as membrane-bound/cytoplasmic beta-catenin.
Recommended Applications: FFPE, Immunofluorescence, Immunohistochemistry, Western Blot